Textbook of Biochemistry
  by DK Tripathi / Ayushmaan Roy / Amit Roy / AK Jha
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   ISBN 978-93-85529-70-2; 1st Ed. 2024, pp.viii+296

   Delhi price: 270      Outside Delhi price: 285      Overseas price : 810

 About The Book  

   Biochemistry deals with the chemical reactions take place in the body of human, plant, animal, or microorganism. It has many applications to the disciplines of pharmacy, veterinary, agriculture, bioengineering and technology.

   This textbook has been prepared as per the syllabus by the Pharmacy Council of India. The syllabus is a blend of pure and applied aspects of biochemistry. This book has been developed with a new orientation so that the importance and significance of the application of biochemistry to pharmacy is empasized. The book contains pre-digested information on biochemistry for good understanding for good understanding, assimilation and reproducibility. The book equips basic as well as applied aspects. Some extra topics have been included which are beyond the syllabus.

   The language has been kept simple to understanding the concepts with ease.


     ƒ Introduction
     ƒ Classification
     ƒ Chemical nature and biological role of bioenergetics
     ƒ Types of bioenergetics reactions
     ƒ Major bioenergetic processes
     ƒ Bioenergetics relationship between free energy, enthalpy and entropy
     ƒ Carbohydrated
     ƒ Classification of carbohydrates
     ƒ Fructose
     ƒ Structure of fructose
     ƒ Nucleic acids
     ƒ Amino acids
     ƒ Proteins
     ƒ Synthesis of proteins

     ƒ Concept of free energy
     ƒ Exergonic reactions
     ƒ Endergonic reactions
     ƒ Free energy
     ƒ Enthalpy
     ƒ Bond enthalpy
     ƒ Entropy
     ƒ Redox potential
     ƒ Energy rich compounds
     ƒ Types of high energy bonds
     ƒ Biological significances of ATP
     ƒ Biochemical functions of ATP
     ƒ Biological significances of cyclic AMP

     ƒ Introduction
     ƒ Glycolysis pathway
     ƒ Major pathways of carbohydrate metabolism
     ƒ Energetics and significance of glycolysis
     ƒ Energetics and significance citric acid cycle
     ƒ Energetics and significance HMP shunt
     ƒ Glycogen metabolism pathways
     ƒ Glycogen storage diseases (GSD)
     ƒ Gluconeogenesis pathway
     ƒ Significance of gluconeogenesis
     ƒ Hormonal regulation of blood glucose level
     ƒ Diabetes Mellitus
     ƒ Insulin resistance

     ƒ Introduction
     ƒ Biological oxidation
     ƒ Significance of biological oxidation
     ƒ Hormonal regulation of blood glucose level
     ƒ Diabetes Mellitus
     ƒ Electron transport chain (ETC)
     ƒ Mechanism of ETC
     ƒ Oxidative phosphorylation
     ƒ Mechanism and substrate phosphorylation inhibitors
     ƒ Uncouplers level
     ƒ Lipid metabolism

     ƒ Β-oxidation of saturated fatty acid (Palmitic acid)
     ƒ Formation and utilization of ketone bodies; Ketoacidosis
     ƒ De novo synthesis of fatty acids (Palmitic acid)
     ƒ Biological significance of cholesterol and Conversion of cholesterol into bile acids
     ƒ Steroid hormone and vitamin D Disorders of lipid metabolism
     ƒ Hypercholesterolemia

     ƒ General reactions of amino acid metabolism
     ƒ Transamination, deamination and decarboxylation,urea cycle and its disorders
     ƒ Catabolism of phenylalanine and tyrosine and their metabolic disorders
     ƒ (Phenyketonuria, Albinism, alkeptonuria, tyrosinemia)
     ƒ Synthesis and significance of biological substances
     ƒ 5-HT, melatonin, dopamine, noradrenaline, adrenaline
     ƒ Catabolism of heme; hyperbilirubinemia and jaundice

     ƒ Biosynthesis of purine and pyrimidine nucleotides
     ƒ Catabolism of purine nucleotides and Hyperuricemia and Gout disease
     ƒ Organization of mammalian genome
     ƒ Structure of DNA and RNA and their functions
     ƒ DNA replication
     ƒ (semi conservative model)
     ƒ Transcription or RNA synthesis
     ƒ Genetic code
     ƒ Translation or Protein synthesis and inhibitors

     ƒ Introduction
     ƒ Properties, nomenclature
     ƒ IUB classification of enzymes ƒ Enzyme kinetics (Michaelis plot, Line Weaver Burke plot)
     ƒ Enzyme inhibitors with examples Regulation of enzymes
     ƒ Enzyme induction and repression
     ƒ Allosteric enzymes regulation
     ƒ Therapeutic and diagnostic applications of enzymes
     ƒ Isoenzymes
     ƒ Coenzymes – Structure and biochemical functions